Prins Bernhard En Prinses Annette

The prins reaction is a very convenient synthetic platform for the preparation of oxygen-containing heterocyclic compounds, especially tetrahydropyr-ans and tetrahydrofurans. Prins cyclization strategies have been proven as a reliable and robust method for the stereoselective construction of thp rings. The application of the prins macrocyclization in the past two years reflects the capacity of this approach to construct a tetrahydropyran ring simultaneously with a macrocycle in a convergent, selective and.

This work expands the substrate scope of such prins cycliza-tions and now enables the inclusion of substrates with electron-donating groups, while maintaining excellent levels of efficiency and. The prins reaction, a con-densation reaction of aldehydes or ketones with olefins or alkynes under acid catalysis, offers an efficient avenue for the construction of carbon-carbon bonds and cyclic compounds. In joined publications, the prins- and frezzato-groups have recently reported a minimalistic chemical reac-tion network that produces a hydrazone using adenosine diphosphate (adp) as a chemical fuel.